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It may be convenient to apply triamcinolone acetonide cream USP, 0.1% under an occlusive dressing in the evening and to remove the dressing in the morning (i.e., 12-hour occlusion). The frequency of changing dressings is best determined on an individual basis. If needed, additional moisture may be provided by covering the lesion with a dampened clean cotton cloth before the nonporous film is applied or by briefly wetting the affected area with water immediately prior to applying the medication. Reapply the preparation leaving a thin coating on the lesion, cover with pliable nonporous film, and seal the edges. Gently rub a small amount of cream into the lesion until it disappears.

Occlusive dressings may be used for the management of psoriasis or other recalcitrant conditions. These preparations are not for ophthalmic use. If a favorable response does not occur promptly, the corticosteroid should be discontinued until the infection has been adequately controlled.

In the presence of dermatological infections, the use of an appropriate antifungal or antibacterial agent should be instituted. If irritation develops, topical corticosteroids should be discontinued and appropriate therapy instituted. Occasionally, a patient may develop a sensitivity reaction to a particular occlusive dressing material or adhesive and a substitute material may be necessary.Ĭhildren may absorb proportionally larger amounts of topical corticosteroids and thus be more susceptible to systemic toxicity (see PRECAUTIONS, Pediatric Use). Infrequently, signs and symptoms of steroid withdrawal may occur, requiring supplemental systemic corticosteroids. Recovery of HPA axis function and thermal homeostasis are generally prompt and complete upon discontinuation of the drug. If HPA axis suppression or elevation of the body temperature occurs, an attempt should be made to withdraw the drug, to reduce the frequency of application, substitute a less potent steroid, or use a sequential approach when utilizing the occlusive technique.

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Therefore, patients receiving a large dose of any potent topical steroid applied to a large surface area or under an occlusive dressing should be evaluated periodically for evidence of HPA axis suppression by using the urinary free cortisol and ACTH stimulation tests, and for impairment of thermal homeostasis. Systemic absorption of topical corticosteroids has produced reversible hypothalamic-pituitary-adrenal (HPA) axis suppression, manifestations of Cushing's syndrome, hyperglycemia, and glucosuria in some patients.Ĭonditions which augment systemic absorption include the application of the more potent steroids, use over large surface areas, prolonged use, and the addition of occlusive dressings. Some of the topical corticosteroids and their metabolites are also excreted into the bile. Corticosteroids are metabolized primarily in the liver and are then excreted by the kidneys.

Once absorbed through the skin, topical corticosteroids are handled through pharmacokinetic pathways similar to systemically administered corticosteroids.Ĭorticosteroids are bound to plasma proteins in varying degrees. Thus, occlusive dressings may be a valuable therapeutic adjunct for treatment of resistant dermatoses (see DOSAGE AND ADMINISTRATION). Occlusive dressings substantially increase the percutaneous absorption of topical corticosteroids.

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Inflammation and/or other disease processes in the skin increase percutaneous absorption.

Topical corticosteroids can be absorbed from normal intact skin. Book your flight today and know that you'll earn Rapid Rewards ® points when you fly.The extent of percutaneous absorption of topical corticosteroids is determined by many factors including the vehicle, the integrity of the epidermal barrier, and the use of occlusive dressings. Want the latest news, information, and promotional offers from Southwest? Sign up to receive email from us. When you search for your next flight to Montrose (Telluride/Crested Butte), CO, know that you won’t be surprised at checkout. Learn more about the Southwest ® travel experience before you book your flight from Cancun International Airport to Montrose Regional Airport.įlying with Southwest is simple and fun, no matter which of our dozens of exciting destinations you choose. So from booking to boarding, we offer services and features designed to make your travel from Cancun to Montrose (Telluride/Crested Butte), CO, the best it can be. At Southwest, we know it takes more than great deals on Montrose (Telluride/Crested Butte), CO, airfares and convenient scheduling options to make your trip memorable.

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